“Isotretinoin might cause growth impairment by inducing premature fusion of the growth plates, which seems to be associated with younger age, incremental doses, and the duration of the therapy, beyond individual susceptibility." https://www.mdpi.com/2673-396X/4/2/23 "Olfactory dysfunction was more prevalent among ISO users, despite the patients being unaware of the disorder." Kondo, R. N., Miot, H. A., Frare, E. Z., Garcia, E. C. D., Yamakami, A. H., & Fornazieri, M. A. (2024). Prevalence and factors associated with olfactory impairment among patients with acne treated with oral isotretinoin: a cross-sectional study. Brazilian journal of otorhinolaryngology, 90(5), 101461. Advance online publication. https://doi.org/10.1016/j.bjorl.2024.101461 todo: testosterone lvls (edited)

TODO: liver function tests, liver ultrasounds, and metabolic marker monitoring is recommended prior to and during taking accutane See https://discord.com/channels/1169738819688468501/1215937459347525652 for markers for acne in general (edited)

Help with side effects

Carnitine

See here: https://discord.com/channels/1169738819688468501/1269630832620998759/1269631740322775131

Dietary Supplement (gamma linolenic acid, vitamin E, vitamin C, beta-carotene, coenzyme Q10 and Vitis Vitifera)

"Results: Patients treated with dietary supplement had lower side effects, with a less degree of erythema and dryness, and greater degree of hydration; a greater adherence to therapy was also reported. " Fabbrocini, G., Cameli, N., Lorenzi, S., De Padova, M. P., Marasca, C., Izzo, R., & Monfrecola, G. (2014). A dietary supplement to reduce side effects of oral isotretinoin therapy in acne patients. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 149(4), 441–445.

Primrose Oil

https://discord.com/channels/1169738819688468501/1261204198545031178/1261204198545031178

Silymarin (milk thistle)

https://discord.com/channels/1169738819688468501/1260494342053691414/1260494342053691414 (edited)

Help with side effects 2

Omega-3

Mirnezami, M., & Rahimi, H. (2018). Is Oral Omega-3 Effective in Reducing Mucocutaneous Side Effects of Isotretinoin in Patients with Acne Vulgaris?. Dermatology research and practice, 2018, 6974045. https://doi.org/10.1155/2018/6974045
Krishna, S (2015). Influence of ω-3 fatty acids on triglyceride levels in patients using isotretinoin. JAMA dermatology, 151(1), 101–102. https://doi.org/10.1001/jamadermatol.2014.2402
Zainab, Z (2021). Effectiveness Of Oral Omega 3 In Reducing Mucocutaneous Side Effects Of Oral Isotretinoin In Patients With Acne Vulgaris.
Mirnezami, M. (2017). Evaluating the Role of Omega 3 on the Side Effects of Isotretinoin in Patients with the Acnea Vulgaris.
Elhamaky T. R. (2021). Efficacy of omega-3 fatty acids and punctal plugs in the prevention of isotretinoin-associated ocular surface disease. European journal of ophthalmology, 31(5), 2339–2345. https://doi.org/10.1177/1120672120945655 ## Biotin

"Biotin (10 mg/day) given in addition to isotretinoin treatment decreased telogen and increased anagen hair rates and helped to maintain skin hydration. The use of 10 mg/day biotin can prevent the mucocutaneous adverse effects of isotretinoin treatment." Aksac, S. E., Bilgili, S. G., Yavuz, G. O., Yavuz, I. H., Aksac, M., & Karadag, A. S. (2021). Evaluation of biophysical skin parameters and hair changes in patients with acne vulgaris treated with isotretinoin, and the effect of biotin use on these parameters. International journal of dermatology, 60(8), 980–985. https://doi.org/10.1111/ijd.15485

Zinc

https://discord.com/channels/1169738819688468501/1179948530878648430/1259090080685883464 (edited)

Efficacy and recurrence

Ghalamkarpour, F., & Nasiri, S. (2006). Isotretinoin in treatment of acne: its efficacy, side effects, and recurrence rate of disease. Archives of Iranian medicine, 9(3), 228–230. TODO: look into recurrence rates and factors that influence this (edited)

Chip changed the channel name: Accutane (Isotretinoin) Side Effects 18/08/2024 4:53 PM

Low dose / intermittent dose

"Conclusion: The oral intermittent Isotretinoin therapy is more effective than daily continuous Isotretinoin therapy in patients with moderate to severe acne vulgaris." Faysal, Lubna Rani, Riffat Iqbal and Bilqees Fatima, ‘Effectiveness Of Oral Intermittent Vs Oral Continuous Isotretinoin Therapy in Patients with Moderate to Severe Acne Vulgaris; A Randomized Controlled Trial’ (2022) 17(1) J. Islamic Int. Med. Coll. 14

Chip changed the channel name: Accutane (Isotretinoin) for acne 18/08/2024 4:54 PM